Tripterin; 3-hydroxy-9β,13α-dimethyl -2-oxo-24,25,26- trinoroleana-1(10),3,5,7-tetraen-29-oic acid
34157-83-0
450.61
C29H38O4
Methanol
2-8°C
Celastrol (also known as Tripterin) is a cell-permeable proteasome inhibitor. Celastrol acts as an antioxidant, anti-inflammatory and immunosuppressive agent. It suppresses LPS-induced cytokine release in macrophages and monocytes (IC= 40 nM for IL-1 and IL-1, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF).
Celastrol suppresses nitric oxide production (IC= 230 nM) and LPS-induced NF-B activation (IC= 270 nM). It inhibits chymotrypsin-like activity of 20S proteasome (IC= 2.5 M) and lipid peroxidation induced by ADP and Fe in rat liver mitochondria (IC= 7 M).
Isolated from Tripterygium wilfordii.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
