Nec-1
4311-88-0
259.3
C13H13N3OS
DMF, DMSO, Ethanol
-20°C
Necrostatin-1 inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC = 180 nM).
0.1 lbs
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Substance Name:N-Debenzoyl-N-(t-butoxycarbonyl)-10-deacetyltaxol; Taxotere; RP-56976; NSC-628503
CAS Number:114977-28-5
