6-bromo-N-2-propen-1-yl-4-quinazolinamine
307538-42-7
264.1
C11H10BrN3
DMF, DMSO, Ethanol
-20°C
SMER28 acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington's Disease (HD).
Maybe a useful lead compound for the development of new therapeutics for neurodegenerative diseases. Induces the release of articular cartilage vesicles from healthy articular chondrocytes in a dose- and time-dependent manner. Promotes reprogramming of fibroblasts to neural stem-like cells. Cell permeable.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
