Quisqualic Acid; Quisqualate; 3-(3,5-Dioxo-1,2,4- oxadiazolidin-2-yl)-L-alanine; β-(3,5-Dioxo-1,2,4- oxadiazolidin-2-yl)-L-alanine; L-(+)-α-Amino-3,5-dioxo1,2,4-oxadiazolidine-2- propanoic acid
52809-07-1
189.13
C5H7N3O5
Water, NaOH
2-8°C
L-Quisqualic Acid is one of the most potent AMPA receptor agonists, causing excitotoxicity -- a process in which nerve cells are killed or damaged due to the overstimulation of neurotransmitters. It is also believed to mimic the excitatory neurotransmitter L-glutamic acid, which is studied in relation to insect neuromuscular function and the mammalian central nervous system.
Commonly used in neuroscience to deliberately kill brain and/or spinal cord neurons, L-Quisqualic Acid is also used to sensitize neurons to depolarization within the hippocampus (known as the "quis effect") -- which is the movement of a cell membrane's potential, making it slightly more positive.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
