P168
76600-38-9
1218.6
C62H111N11O13
DMF, DMSO, Ethanol, Methanol
-20°C
Leucinostatin A is the major component of atypical nonapeptide complex and a fungal metabolite isolated from Paecilomyces lilacinus. Leucinostatins show broad bioactivity against Gram-positive bacteria, fungi, plants and tumor cell lines. It inhibits respiration by uncoupling oxidative phosphorylation and is potentiated by inhibitors such as venturicidin and oligomycin.
It is believed that leucinostatin A suppresses the activation of T lymphocytes. It acts as a weak ionophore facilitating the transport of mono- and divalent cations through the plasma membrane of T lymphocytes and through artificial membranes.
It has been reported that it has an activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity.
Applications
• Antibiotic
• Ionophore
• Immunosuppressive agent
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
