APC; ICI 69653; NSC 234714
38966-21-1
338.5
C20H34O4
DMSO, Methanol
-20°C
Aphidicolin is a reversible inhibitor of nuclear DNA replication in eukaryotes and some animal viruses. It interferes with dCTP-specific binding sites on DNA polymerase-α. It also works on other DNA polymerases, however it does not work on DNA polymerase-β.
Viruses inducing DNA polymerase-α, such as Herpes simplex, can be affected by aphidicolin because of its mechanism. It could be used for clinical study.
Isolated from Nigrospora oryzae.
Applications:
- Control of cell proliferation
- DNA pol-β studies
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
