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GSK-J4, 25 MG

Price$ 250.00
  • SKU: G-3006-25MG
  • Pack Size: 25 MG
Quantity
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N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine, ethyl ester

1373423-53-0

417.5

C24H27N5O2

DMSO, Ethanol

-20°C


GSK-J4 is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK-J1. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies. Inhibits the growth of T-cell acute lymphoblastic leukemia (T-ALL) cells. Useful tool for studying the role of JMJD3 in cellular physiology.

 



Research or further manufacturing use only, not for food or drug use.

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