Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]
183506-66-3
623.8
C34H49N5O6
DMSO
-20°C
Apicidin is a novel fungal metabolite that is a potent chemotherapeutic and anti-protozoal agent, exhibiting anti-histone deacetylase activity.
It inhibits cell proliferation and antitumor effects in several human cancer cell lines by inducing apoptosis via Fas/Fas ligand. The metabolite arrests the cell cycle at the G1 phase and induces p21 and gelsolin, therefore, it has shown a potential antiproliferative property.
It is used for treatment of parasites in vitro due to its target, histone deacetylase. The acetylation and deacetylation of histones are considered essential in gene expression and it has been proven that histone deacetylation inhibitors have antiparasitic effects.
Applications:
• Chemotherapeutic agent
• Antiprotozoal agent
• Used as an inhibitor of histone deacetylation
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
